Assay Detail
Binding
CHEMBL3863992
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methylspiperone from human D4R expressed in HEK293 cell membranes incubated for 1 hr by radioligand binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.22 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3126735 | — | — | 1 | 7.55 |
| CHEMBL8946 | ETICLOPRIDE | 2.0 | 1 | 7.15 |
| CHEMBL11493 | — | — | 1 | 6.23 |
| CHEMBL3918282 | — | — | 1 | 5.76 |
| CHEMBL3931765 | — | — | 1 | 5.42 |
| CHEMBL3916231 | — | — | 1 | 5.20 |
| CHEMBL1201192 | ARMODAFINIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3126735 | — | Ki | = | 28.1 | nM | 7.55 |
| CHEMBL8946 | ETICLOPRIDE | Ki | = | 70.4 | nM | 7.15 |
| CHEMBL11493 | — | Ki | = | 583.0 | nM | 6.23 |
| CHEMBL3918282 | — | Ki | = | 1750.0 | nM | 5.76 |
| CHEMBL3931765 | — | Ki | = | 3820.0 | nM | 5.42 |
| CHEMBL3916231 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL1201192 | ARMODAFINIL | Ki | > | 100000.0 | nM | - |