Assay Detail
Binding
CHEMBL3863997
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at DRD2 (unknown origin) expressed in HEK293T cells transfected with Galphai1-RLuc8 and gamma2-GFP10 assessed as inhibition of quinpirole-induced Gi1 activation pre-incubated with quinpirole for 10 mins before compound incubation for 10 mins by BRET assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.19 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201192 | ARMODAFINIL | 4.0 | 1 | 8.68 |
| CHEMBL3126735 | — | — | 1 | 5.70 |
| CHEMBL11493 | — | — | 1 | - |
| CHEMBL3916231 | — | — | 1 | - |
| CHEMBL3931765 | — | — | 1 | - |
| CHEMBL3918282 | — | — | 1 | - |
| CHEMBL8946 | ETICLOPRIDE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201192 | ARMODAFINIL | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3126735 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL11493 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3916231 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3931765 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3918282 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL8946 | ETICLOPRIDE | IC50 | > | 10000.0 | nM | - |