Assay Detail
Binding
CHEMBL3863998
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]WIN35,428 from human DAT Y156F mutant expressed in COS7 cell membranes incubated for >90 mins by radioligand binding assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.85 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3918282 | — | — | 1 | 7.01 |
| CHEMBL11493 | — | — | 1 | 6.58 |
| CHEMBL3916231 | — | — | 1 | 6.57 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.49 |
| CHEMBL3126735 | — | — | 1 | 5.69 |
| CHEMBL1672355 | (S)-MODAFINIL | — | 1 | 5.23 |
| CHEMBL1201192 | ARMODAFINIL | 4.0 | 1 | 5.05 |
| CHEMBL3931765 | — | — | 1 | 5.04 |
| CHEMBL1373 | MODAFINIL | 4.0 | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3918282 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL11493 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL3916231 | — | Ki | = | 267.0 | nM | 6.57 |
| CHEMBL370805 | COCAINE | Ki | = | 321.0 | nM | 6.49 |
| CHEMBL3126735 | — | Ki | = | 2050.0 | nM | 5.69 |
| CHEMBL1672355 | (S)-MODAFINIL | Ki | = | 5910.0 | nM | 5.23 |
| CHEMBL1201192 | ARMODAFINIL | Ki | = | 8920.0 | nM | 5.05 |
| CHEMBL3931765 | — | Ki | = | 9170.0 | nM | 5.04 |
| CHEMBL1373 | MODAFINIL | Ki | = | 9250.0 | nM | 5.03 |