Assay Detail
Functional
CHEMBL3864070
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticoxsackie activity against CVB3 strain Nancy infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 4 hrs by XTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Coxsackievirus B3 |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.63 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3939697 | — | — | 1 | 7.92 |
| CHEMBL3920652 | — | — | 1 | 7.77 |
| CHEMBL3923414 | — | — | 1 | 7.42 |
| CHEMBL3947384 | — | — | 1 | 7.25 |
| CHEMBL3976651 | — | — | 1 | 7.24 |
| CHEMBL3894217 | — | — | 1 | 7.08 |
| CHEMBL3948449 | — | — | 1 | 6.86 |
| CHEMBL3957128 | — | — | 1 | 6.82 |
| CHEMBL3958915 | — | — | 1 | 6.32 |
| CHEMBL3959713 | — | — | 1 | 5.96 |
| CHEMBL3930509 | — | — | 1 | 5.88 |
| CHEMBL3911522 | — | — | 1 | 5.78 |
| CHEMBL3902513 | — | — | 1 | 5.30 |
| CHEMBL3893537 | — | — | 1 | 5.28 |
| CHEMBL3929556 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3939697 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3920652 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3923414 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3947384 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3976651 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3894217 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3948449 | — | EC50 | = | 138.0 | nM | 6.86 |
| CHEMBL3957128 | — | EC50 | = | 151.0 | nM | 6.82 |
| CHEMBL3958915 | — | EC50 | = | 476.0 | nM | 6.32 |
| CHEMBL3959713 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3930509 | — | EC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL3911522 | — | EC50 | = | 1661.0 | nM | 5.78 |
| CHEMBL3902513 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3893537 | — | EC50 | = | 5310.0 | nM | 5.28 |
| CHEMBL3929556 | — | EC50 | < | 20.0 | nM | - |