Assay Detail
Functional
CHEMBL3864071
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Antiviral activity against HCV 1b infected in human HuH7-lunet cells after 3 days by Dual-Glo luciferase assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.19 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3920652 | — | — | 1 | 7.70 |
| CHEMBL3976651 | — | — | 1 | 7.54 |
| CHEMBL3957128 | — | — | 1 | 6.46 |
| CHEMBL3959713 | — | — | 1 | 6.41 |
| CHEMBL3929556 | — | — | 1 | 6.38 |
| CHEMBL3930509 | — | — | 1 | 6.23 |
| CHEMBL3939697 | — | — | 1 | 6.18 |
| CHEMBL3948449 | — | — | 1 | 6.02 |
| CHEMBL3894217 | — | — | 1 | 5.99 |
| CHEMBL3923414 | — | — | 1 | 5.99 |
| CHEMBL3902513 | — | — | 1 | 5.74 |
| CHEMBL3893537 | — | — | 1 | 5.57 |
| CHEMBL3911522 | — | — | 1 | 5.47 |
| CHEMBL3947384 | — | — | 1 | 5.04 |
| CHEMBL3958915 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3920652 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3976651 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3957128 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3959713 | — | EC50 | = | 393.0 | nM | 6.41 |
| CHEMBL3929556 | — | EC50 | = | 416.0 | nM | 6.38 |
| CHEMBL3930509 | — | EC50 | = | 594.0 | nM | 6.23 |
| CHEMBL3939697 | — | EC50 | = | 667.0 | nM | 6.18 |
| CHEMBL3948449 | — | EC50 | = | 954.0 | nM | 6.02 |
| CHEMBL3894217 | — | EC50 | = | 1025.0 | nM | 5.99 |
| CHEMBL3923414 | — | EC50 | = | 1033.0 | nM | 5.99 |
| CHEMBL3902513 | — | EC50 | = | 1826.0 | nM | 5.74 |
| CHEMBL3893537 | — | EC50 | = | 2681.0 | nM | 5.57 |
| CHEMBL3911522 | — | EC50 | = | 3415.0 | nM | 5.47 |
| CHEMBL3947384 | — | EC50 | = | 9196.0 | nM | 5.04 |
| CHEMBL3958915 | — | EC50 | < | 20.0 | nM | - |