Assay Detail
Functional
CHEMBL3864072
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Antiviral activity against HCV 2a JFH1 infected in HUH 7-lunet cells after 3 days by Dual-Glo luciferase assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | HUH 7-lunet |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 4.76 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3957128 | — | — | 1 | 5.07 |
| CHEMBL3959713 | — | — | 1 | 5.06 |
| CHEMBL3958915 | — | — | 1 | 5.03 |
| CHEMBL3976651 | — | — | 1 | 4.84 |
| CHEMBL3939697 | — | — | 1 | 4.70 |
| CHEMBL3920652 | — | — | 1 | 4.69 |
| CHEMBL3947384 | — | — | 1 | 4.58 |
| CHEMBL3894217 | — | — | 1 | 4.58 |
| CHEMBL3929556 | — | — | 1 | 4.55 |
| CHEMBL3893537 | — | — | 1 | 4.45 |
| CHEMBL3948449 | — | — | 1 | - |
| CHEMBL3923414 | — | — | 1 | - |
| CHEMBL3930509 | — | — | 1 | - |
| CHEMBL3902513 | — | — | 1 | - |
| CHEMBL3911522 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3957128 | — | EC50 | = | 8506.0 | nM | 5.07 |
| CHEMBL3959713 | — | EC50 | = | 8689.0 | nM | 5.06 |
| CHEMBL3958915 | — | EC50 | = | 9439.0 | nM | 5.03 |
| CHEMBL3976651 | — | EC50 | = | 14402.0 | nM | 4.84 |
| CHEMBL3939697 | — | EC50 | = | 20147.0 | nM | 4.70 |
| CHEMBL3920652 | — | EC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL3947384 | — | EC50 | = | 26540.0 | nM | 4.58 |
| CHEMBL3894217 | — | EC50 | = | 25988.0 | nM | 4.58 |
| CHEMBL3929556 | — | EC50 | = | 27940.0 | nM | 4.55 |
| CHEMBL3893537 | — | EC50 | = | 35923.0 | nM | 4.45 |
| CHEMBL3948449 | — | EC50 | > | 44444.0 | nM | - |
| CHEMBL3923414 | — | EC50 | > | 44444.0 | nM | - |
| CHEMBL3930509 | — | EC50 | > | 44444.0 | nM | - |
| CHEMBL3902513 | — | EC50 | > | 44444.0 | nM | - |
| CHEMBL3911522 | — | EC50 | > | 44444.0 | nM | - |