Assay Detail
Binding
CHEMBL3864384
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Displacement of biotinylated ligand from CBP (unknown origin) by TR-FRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.71 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3622373 | — | — | 1 | 7.52 |
| CHEMBL3963965 | — | — | 1 | 6.72 |
| CHEMBL3774655 | — | — | 1 | 6.36 |
| CHEMBL3752296 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3622373 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3963965 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3774655 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3752296 | — | IC50 | = | 580.0 | nM | 6.24 |