Assay Detail
Binding
CHEMBL3865028
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Inhibition of Hepatitis C virus genotype 1a H77 replicon NS5A Y93H mutant transfected in human HuH7 cells assessed as decrease in replication of viral replicon after 4 days by luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus (isolate H77) |
| Cell Type | Huh-7 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of fluorobenzimidazole HCV NS5A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 9.74 | 10.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3985488 | — | — | 1 | 10.23 |
| CHEMBL3977398 | — | — | 1 | 10.10 |
| CHEMBL3960757 | — | — | 1 | 9.32 |
| CHEMBL3915742 | — | — | 1 | 9.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3985488 | — | EC50 | = | 0.059 | nM | 10.23 |
| CHEMBL3977398 | — | EC50 | = | 0.08 | nM | 10.10 |
| CHEMBL3960757 | — | EC50 | = | 0.477 | nM | 9.32 |
| CHEMBL3915742 | — | EC50 | = | 0.491 | nM | 9.31 |