Assay Detail
Binding
CHEMBL3865046
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Plasmodium falciparum CDPK4 expressed in Escherichia coli Rosetta Oxford using Syntide 2 as substrate assessed as decrease in depletion of ATP by Kinase glo luciferase assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.16 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3108997 | — | — | 1 | 7.51 |
| CHEMBL3108998 | — | — | 1 | 7.44 |
| CHEMBL3109011 | — | — | 1 | 7.43 |
| CHEMBL3108912 | — | — | 1 | 7.41 |
| CHEMBL3770409 | — | — | 1 | 7.36 |
| CHEMBL3770142 | — | — | 1 | 7.32 |
| CHEMBL3770980 | — | — | 1 | 7.31 |
| CHEMBL3770425 | — | — | 1 | 7.24 |
| CHEMBL3771306 | — | — | 1 | 7.24 |
| CHEMBL3985876 | — | — | 1 | 7.15 |
| CHEMBL3108913 | — | — | 1 | 7.13 |
| CHEMBL3908956 | — | — | 1 | 7.13 |
| CHEMBL3770299 | — | — | 1 | 7.12 |
| CHEMBL3108991 | — | — | 1 | 7.11 |
| CHEMBL3770649 | — | — | 1 | 7.10 |
| CHEMBL3770743 | — | — | 1 | 7.09 |
| CHEMBL3922900 | — | — | 1 | 7.09 |
| CHEMBL3770313 | — | — | 1 | 7.09 |
| CHEMBL3769900 | — | — | 1 | 7.09 |
| CHEMBL3769798 | — | — | 1 | 7.08 |
| CHEMBL3769623 | — | — | 1 | 7.05 |
| CHEMBL3770760 | — | — | 1 | 7.03 |
| CHEMBL3770802 | — | — | 1 | 7.03 |
| CHEMBL3108986 | — | — | 1 | 7.03 |
| CHEMBL3922004 | — | — | 1 | 6.99 |
| CHEMBL3973192 | — | — | 1 | 6.99 |
| CHEMBL3956316 | — | — | 1 | 6.95 |
| CHEMBL3916476 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3108997 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3108998 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3109011 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3108912 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3770409 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL3770142 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3770980 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3770425 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL3771306 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3985876 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3108913 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL3908956 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL3770299 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3108991 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3770649 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3770743 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL3922900 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL3770313 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL3769900 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL3769798 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3769623 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3770760 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3770802 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3108986 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3922004 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL3973192 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL3956316 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL3916476 | — | IC50 | = | 123.0 | nM | 6.91 |