Assay Detail
Binding
CHEMBL3865060
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 4.74 | 4.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770802 | — | — | 1 | 4.85 |
| CHEMBL3770409 | — | — | 1 | 4.73 |
| CHEMBL3770313 | — | — | 1 | 4.64 |
| CHEMBL3108997 | — | — | 1 | - |
| CHEMBL3770425 | — | — | 1 | - |
| CHEMBL3108913 | — | — | 1 | - |
| CHEMBL3109011 | — | — | 1 | - |
| CHEMBL3108991 | — | — | 1 | - |
| CHEMBL3770743 | — | — | 1 | - |
| CHEMBL3908956 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770802 | — | EC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL3770409 | — | EC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL3770313 | — | EC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL3108997 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3770425 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL3108913 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL3109011 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL3108991 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL3770743 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL3908956 | — | EC50 | > | 30000.0 | nM | - |