Assay Detail
Functional
CHEMBL3865514
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Induction of human U937 cell differentiation after 4 days by flow cytometry
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 5.40 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 7.36 |
| CHEMBL3188954 | — | — | 1 | 5.62 |
| CHEMBL3184096 | — | — | 1 | 5.57 |
| CHEMBL3184332 | — | — | 1 | 5.38 |
| CHEMBL3188811 | — | — | 1 | 5.36 |
| CHEMBL3914938 | — | — | 1 | 5.25 |
| CHEMBL3186954 | — | — | 1 | 5.25 |
| CHEMBL1237007 | — | — | 1 | 5.21 |
| CHEMBL3186409 | — | — | 1 | 5.06 |
| CHEMBL3184132 | — | — | 1 | 5.06 |
| CHEMBL3187986 | — | — | 1 | 4.92 |
| CHEMBL2043303 | — | — | 1 | 4.77 |
| CHEMBL1332971 | CLONIXIN | 2.0 | 1 | - |
| CHEMBL63323 | NIFLUMIC ACID | 2.0 | 1 | - |
| CHEMBL1617398 | FLUNIXIN | 2.0 | 1 | - |
| CHEMBL1596993 | — | — | 1 | - |
| CHEMBL3961002 | — | — | 1 | - |
| CHEMBL3891124 | — | — | 1 | - |
| CHEMBL3916793 | — | — | 1 | - |
| CHEMBL3944693 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38434 | BREQUINAR | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL3188954 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3184096 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3184332 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3188811 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3914938 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3186954 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1237007 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3186409 | — | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL3184132 | — | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL3187986 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2043303 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1332971 | CLONIXIN | EC50 | > | 20000.0 | nM | - |
| CHEMBL63323 | NIFLUMIC ACID | EC50 | > | 20000.0 | nM | - |
| CHEMBL1617398 | FLUNIXIN | EC50 | > | 20000.0 | nM | - |
| CHEMBL1596993 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3961002 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3891124 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3916793 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3944693 | — | EC50 | > | 20000.0 | nM | - |