Assay Detail
Binding
CHEMBL3865595
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Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of an Orally Efficacious GPR40/FFAR1 Receptor Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 8.16 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3922381 | — | — | 1 | 9.10 |
| CHEMBL3904378 | — | — | 1 | 8.85 |
| CHEMBL3896509 | — | — | 1 | 8.72 |
| CHEMBL1829174 | FASIGLIFAM | 3.0 | 1 | 8.72 |
| CHEMBL3966739 | — | — | 1 | 8.72 |
| CHEMBL3923431 | — | — | 1 | 8.70 |
| CHEMBL3889768 | — | — | 1 | 8.68 |
| CHEMBL1829173 | — | — | 1 | 8.66 |
| CHEMBL3924534 | — | — | 1 | 8.36 |
| CHEMBL3951157 | — | — | 1 | 8.34 |
| CHEMBL3918387 | — | — | 1 | 8.15 |
| CHEMBL3914686 | — | — | 1 | 8.11 |
| CHEMBL3914418 | — | — | 1 | 8.10 |
| CHEMBL3975239 | — | — | 1 | 8.07 |
| CHEMBL3913383 | — | — | 1 | 8.07 |
| CHEMBL3893141 | — | — | 1 | 8.00 |
| CHEMBL3957744 | — | — | 1 | 7.92 |
| CHEMBL3895442 | — | — | 1 | 7.79 |
| CHEMBL3933446 | — | — | 1 | 7.78 |
| CHEMBL3921143 | — | — | 1 | 7.53 |
| CHEMBL3894356 | — | — | 1 | 7.42 |
| CHEMBL3931296 | — | — | 1 | 6.93 |
| CHEMBL3905435 | — | — | 1 | 6.85 |
| CHEMBL3964251 | — | — | 1 | - |
| CHEMBL3902108 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3922381 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3904378 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3896509 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1829174 | FASIGLIFAM | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3966739 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3923431 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3889768 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL1829173 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3924534 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3951157 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL3918387 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3914686 | — | EC50 | = | 7.7 | nM | 8.11 |
| CHEMBL3914418 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL3975239 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL3913383 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL3893141 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3957744 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3895442 | — | EC50 | = | 16.1 | nM | 7.79 |
| CHEMBL3933446 | — | EC50 | = | 16.7 | nM | 7.78 |
| CHEMBL3921143 | — | EC50 | = | 29.6 | nM | 7.53 |
| CHEMBL3894356 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3931296 | — | EC50 | = | 118.3 | nM | 6.93 |
| CHEMBL3905435 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3964251 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL3902108 | — | EC50 | - | — | - |