Assay Detail
Binding
CHEMBL3865724
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FAM-Bid binding to human MCL1 expressed in Escherichia coli BL21 after 30 mins by fluorescence polarization assay
24
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Gossypol with Hydrophobic Linear Esters Exhibits Enhanced Antitumor Activity as an Inhibitor of Antiapoptotic Proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.03 | 6.32 |
| Ki | 12 | 6.75 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1962393 | — | — | 2 | 7.07 |
| CHEMBL3951720 | — | — | 2 | 7.03 |
| CHEMBL1962390 | — | — | 2 | 6.92 |
| CHEMBL3932954 | — | — | 2 | 6.86 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 2 | 6.79 |
| CHEMBL3918448 | — | — | 6 | 6.75 |
| CHEMBL3971530 | — | — | 2 | 6.71 |
| CHEMBL3929718 | — | — | 2 | 6.56 |
| CHEMBL3957283 | — | — | 2 | 6.24 |
| CHEMBL3137309 | VENETOCLAX | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1962393 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL3951720 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL1962390 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL3932954 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL51483 | GOSSYPOL | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL3918448 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL3918448 | — | Ki | = | 178.0 | nM | 6.75 |
| CHEMBL3971530 | — | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL3918448 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL3929718 | — | Ki | = | 276.0 | nM | 6.56 |
| CHEMBL1962393 | — | IC50 | = | 478.0 | nM | 6.32 |
| CHEMBL1962390 | — | IC50 | = | 521.0 | nM | 6.28 |
| CHEMBL3957283 | — | Ki | = | 579.0 | nM | 6.24 |
| CHEMBL3951720 | — | IC50 | = | 661.0 | nM | 6.18 |
| CHEMBL3932954 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL51483 | GOSSYPOL | IC50 | = | 856.0 | nM | 6.07 |
| CHEMBL3918448 | — | IC50 | = | 937.0 | nM | 6.03 |
| CHEMBL3918448 | — | IC50 | = | 947.0 | nM | 6.02 |
| CHEMBL3971530 | — | IC50 | = | 1021.0 | nM | 5.99 |
| CHEMBL3918448 | — | IC50 | = | 1249.0 | nM | 5.90 |
| CHEMBL3929718 | — | IC50 | = | 1433.0 | nM | 5.84 |
| CHEMBL3957283 | — | IC50 | = | 2959.0 | nM | 5.53 |
| CHEMBL3137309 | VENETOCLAX | IC50 | > | 4000.0 | nM | - |
| CHEMBL3137309 | VENETOCLAX | Ki | > | 780.0 | nM | - |