Assay Detail
Binding
CHEMBL3865725
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Inhibition of FAM-Bid binding to human BCL2 expressed in Escherichia coli BL21 after 30 mins by fluorescence polarization assay
24
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Gossypol with Hydrophobic Linear Esters Exhibits Enhanced Antitumor Activity as an Inhibitor of Antiapoptotic Proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.32 | 6.99 |
| Ki | 12 | 6.82 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3929718 | — | — | 2 | 8.30 |
| CHEMBL3957283 | — | — | 2 | 7.05 |
| CHEMBL3918448 | — | — | 6 | 6.88 |
| CHEMBL1962393 | — | — | 2 | 6.77 |
| CHEMBL3932954 | — | — | 2 | 6.74 |
| CHEMBL1962390 | — | — | 2 | 6.65 |
| CHEMBL3951720 | — | — | 2 | 6.63 |
| CHEMBL3971530 | — | — | 2 | 6.46 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 2 | 6.29 |
| CHEMBL3137309 | VENETOCLAX | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3929718 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL3957283 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL3929718 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL3918448 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL3918448 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL1962393 | — | Ki | = | 171.0 | nM | 6.77 |
| CHEMBL3932954 | — | Ki | = | 182.0 | nM | 6.74 |
| CHEMBL1962390 | — | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL3951720 | — | Ki | = | 235.0 | nM | 6.63 |
| CHEMBL3957283 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL3918448 | — | Ki | = | 341.0 | nM | 6.47 |
| CHEMBL3971530 | — | Ki | = | 348.0 | nM | 6.46 |
| CHEMBL3918448 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL1962393 | — | IC50 | = | 458.0 | nM | 6.34 |
| CHEMBL3918448 | — | IC50 | = | 452.0 | nM | 6.34 |
| CHEMBL3932954 | — | IC50 | = | 483.0 | nM | 6.32 |
| CHEMBL51483 | GOSSYPOL | Ki | = | 511.0 | nM | 6.29 |
| CHEMBL1962390 | — | IC50 | = | 573.0 | nM | 6.24 |
| CHEMBL3951720 | — | IC50 | = | 596.0 | nM | 6.22 |
| CHEMBL3971530 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL3918448 | — | IC50 | = | 825.0 | nM | 6.08 |
| CHEMBL51483 | GOSSYPOL | IC50 | = | 1191.0 | nM | 5.92 |
| CHEMBL3137309 | VENETOCLAX | IC50 | < | 1.0 | nM | - |
| CHEMBL3137309 | VENETOCLAX | Ki | < | 1.0 | nM | - |