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Assay Detail

CHEMBL3865860

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Binding
Inhibition of Escherichia coli FtsZ polymerization expressed in Escherichia coli BL21 assessed as reduction in light scattering intensity in presence of GTP by fluorescence spectrometric analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ.
Haranahalli K, Tong S, Ojima I.
Bioorg Med Chem (2016) 24 : 6354 -6369
PubMed 27189886 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 4.23 4.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL71851 SCOPOLETIN 1 4.39
CHEMBL284616 CHLOROGENIC ACID 2.0 1 4.16
CHEMBL244948 DAPHNETIN -1.0 1 4.14
CHEMBL42710 EUGENOL 0.5 1 -
CHEMBL3931155 1 -
CHEMBL320295 O,O'-DIMETHYLCAFFEIC ACID 1 -
CHEMBL145 CAFFEIC ACID 3.0 1 -
CHEMBL66879 COUMARIC ACID 1 -
CHEMBL27246 CINNAMIC ACID 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL71851 SCOPOLETIN IC50 = 41000.0 nM 4.39
CHEMBL284616 CHLOROGENIC ACID IC50 = 69550.0 nM 4.16
CHEMBL244948 DAPHNETIN IC50 = 73000.0 nM 4.14
CHEMBL42710 EUGENOL IC50 > 250000.0 nM -
CHEMBL3931155 IC50 = 148590.0 nM -
CHEMBL320295 O,O'-DIMETHYLCAFFEIC ACID IC50 > 250000.0 nM -
CHEMBL145 CAFFEIC ACID IC50 = 105960.0 nM -
CHEMBL66879 COUMARIC ACID IC50 = 189530.0 nM -
CHEMBL27246 CINNAMIC ACID IC50 = 238970.0 nM -