Assay Detail
Binding
CHEMBL3867190
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NAMPT in human A2780 cells assessed as decrease in cell viability after 72 hrs by SRB assay
63
Total Activities
63
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nicotinamide phosphoribosyltransferase (CHEMBL1744525) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 63 | 7.97 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3968268 | — | — | 1 | 9.40 |
| CHEMBL3916438 | — | — | 1 | 9.22 |
| CHEMBL3948584 | — | — | 1 | 9.00 |
| CHEMBL17289 | CHS-828 | 1.0 | 1 | 9.00 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 9.00 |
| CHEMBL3986197 | — | — | 1 | 9.00 |
| CHEMBL3963163 | — | — | 1 | 8.80 |
| CHEMBL3893879 | — | — | 1 | 8.80 |
| CHEMBL3958233 | — | — | 1 | 8.80 |
| CHEMBL3913883 | — | — | 1 | 8.80 |
| CHEMBL2420629 | — | — | 1 | 8.70 |
| CHEMBL3983716 | — | — | 1 | 8.66 |
| CHEMBL3984355 | — | — | 1 | 8.46 |
| CHEMBL3923552 | — | — | 1 | 8.42 |
| CHEMBL3974268 | — | — | 1 | 8.40 |
| CHEMBL3260358 | — | — | 1 | 8.40 |
| CHEMBL3939767 | — | — | 1 | 8.37 |
| CHEMBL3925878 | — | — | 1 | 8.36 |
| CHEMBL3948512 | — | — | 1 | 8.32 |
| CHEMBL2420620 | — | — | 1 | 8.30 |
| CHEMBL3914526 | — | — | 1 | 8.28 |
| CHEMBL3889487 | — | — | 1 | 8.24 |
| CHEMBL3394734 | — | — | 1 | 8.22 |
| CHEMBL3127521 | — | — | 1 | 8.22 |
| CHEMBL3897803 | — | — | 1 | 8.22 |
| CHEMBL3949594 | — | — | 1 | 8.21 |
| CHEMBL3940454 | — | — | 1 | 8.19 |
| CHEMBL3904503 | — | — | 1 | 8.16 |
| CHEMBL3921809 | — | — | 1 | 8.12 |
| CHEMBL2419504 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3968268 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3916438 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL17289 | CHS-828 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL566757 | DAPORINAD | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3986197 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3948584 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3963163 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3893879 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3958233 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3913883 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2420629 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3983716 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3984355 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3923552 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL3260358 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3974268 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3939767 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3925878 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3948512 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL2420620 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3914526 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3889487 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL3394734 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3127521 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3897803 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3949594 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL3940454 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3904503 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL3921809 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL2419504 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3394738 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2419515 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3913503 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL2417572 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3932498 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL2419505 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3908644 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3930755 | — | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL3941475 | — | IC50 | = | 24.8 | nM | 7.61 |
| CHEMBL3907541 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3977721 | — | IC50 | = | 29.4 | nM | 7.53 |
| CHEMBL3895553 | — | IC50 | = | 31.2 | nM | 7.51 |
| CHEMBL2391568 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3920776 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3921880 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3986623 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3972073 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2393183 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2393163 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL3981065 | — | IC50 | = | 101.0 | nM | 7.00 |