Assay Detail
Binding
CHEMBL3867372
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Inhibition of Toxoplasma gondii TS-DHFR expressed in Escherichia coli BL21 preincubated for 15 mins followed by addition of DHF as substrate and NADPH measured after 60 mins by resazurin/diaphorase coupled assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL2425) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.26 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3953119 | — | — | 1 | 8.06 |
| CHEMBL3953069 | — | — | 1 | 7.77 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.15 |
| CHEMBL3901807 | — | — | 1 | 6.70 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 6.64 |
| CHEMBL3912823 | — | — | 1 | 6.43 |
| CHEMBL3980903 | — | — | 1 | 6.34 |
| CHEMBL3910843 | — | — | 1 | 6.04 |
| CHEMBL3972872 | — | — | 1 | 6.02 |
| CHEMBL3963161 | — | — | 1 | 6.01 |
| CHEMBL3921798 | — | — | 1 | 5.96 |
| CHEMBL3958219 | — | — | 1 | 5.62 |
| CHEMBL3970251 | — | — | 1 | 5.57 |
| CHEMBL3940818 | — | — | 1 | 5.52 |
| CHEMBL3930739 | — | — | 1 | 4.10 |
| CHEMBL3949585 | — | — | 1 | - |
| CHEMBL3906933 | — | — | 1 | - |
| CHEMBL3892841 | — | — | 1 | - |
| CHEMBL3936777 | — | — | 1 | - |
| CHEMBL3962899 | — | — | 1 | - |
| CHEMBL3924966 | — | — | 1 | - |
| CHEMBL3948504 | — | — | 1 | - |
| CHEMBL3935452 | — | — | 1 | - |
| CHEMBL3896873 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3953119 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL3953069 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3901807 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3912823 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3980903 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3910843 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL3972872 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL3963161 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL3921798 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3958219 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3970251 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3940818 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3930739 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL3949585 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3906933 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3892841 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3936777 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3962899 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3924966 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3948504 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3935452 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3896873 | — | IC50 | > | 10000.0 | nM | - |