Assay Detail
Binding
CHEMBL3867378
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminus 6xHis-tagged human IDO1 expressed in Escherichia coli M15 using L-tryptophan as substrate preincubated for 1 hr measured after 15 mins in presence of bovine liver and methylene blue by HPLC analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fused Heterocyclic Compounds as Potent Indoleamine-2,3-dioxygenase 1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.11 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3909480 | — | — | 1 | 7.11 |
| CHEMBL3913975 | — | — | 1 | 7.11 |
| CHEMBL3971895 | — | — | 1 | 7.11 |
| CHEMBL3971417 | — | — | 1 | 7.11 |
| CHEMBL3930308 | — | — | 1 | 7.11 |
| CHEMBL3940383 | — | — | 1 | 7.11 |
| CHEMBL3913434 | — | — | 1 | 7.11 |
| CHEMBL3945146 | — | — | 1 | 7.11 |
| CHEMBL3974564 | — | — | 1 | 7.11 |
| CHEMBL3936225 | — | — | 1 | 7.11 |
| CHEMBL3966057 | — | — | 1 | 7.11 |
| CHEMBL3927265 | — | — | 1 | 7.11 |
| CHEMBL584991 | — | — | 1 | 7.11 |
| CHEMBL504816 | (L)-1-METHYLTRYPTOPHAN | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3909480 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3913975 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3971895 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3971417 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3930308 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3940383 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3913434 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3945146 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3974564 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3936225 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3966057 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3927265 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL584991 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL504816 | (L)-1-METHYLTRYPTOPHAN | IC50 | = | 78.0 | nM | 7.11 |