Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3868075

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of Cyp19 (unknown origin)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Aromatase (CHEMBL1978)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis, and evaluation of (2S,4R)-Ketoconazole sulfonamide analogs as potential treatments for Metabolic Syndrome.
Blass BE, Iyer P, Abou-Gharbia M, Childers WE, Gordon JC, Ramanjulu M, Morton G, Arumugam P, Boruwa J, Ellingboe J, Mitra S, Nimmareddy RR, Paliwal S, Rajasekhar J, Shivakumar S, Srivastava P, Tangirala RS, Venkataramanaiah K, Yanamandra M.
Bioorg Med Chem Lett (2016) 26 : 5825 -5829
PubMed 27789139 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.63 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3938615 1 6.10
CHEMBL3983734 1 6.01
CHEMBL3980889 1 6.00
CHEMBL3894912 1 5.92
CHEMBL3931836 1 5.91
CHEMBL157101 KETOCONAZOLE 4.0 1 5.80
CHEMBL3913908 1 5.80
CHEMBL3922888 1 5.74
CHEMBL3952032 1 5.55
CHEMBL3968178 1 5.42
CHEMBL3964421 1 5.00
CHEMBL3960724 1 5.00
CHEMBL3891718 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3938615 IC50 = 790.0 nM 6.10
CHEMBL3983734 IC50 = 970.0 nM 6.01
CHEMBL3980889 IC50 = 1000.0 nM 6.00
CHEMBL3894912 IC50 = 1200.0 nM 5.92
CHEMBL3931836 IC50 = 1240.0 nM 5.91
CHEMBL157101 KETOCONAZOLE IC50 = 1600.0 nM 5.80
CHEMBL3913908 IC50 = 1600.0 nM 5.80
CHEMBL3922888 IC50 = 1820.0 nM 5.74
CHEMBL3952032 IC50 = 2800.0 nM 5.55
CHEMBL3968178 IC50 = 3800.0 nM 5.42
CHEMBL3964421 IC50 = 10000.0 nM 5.00
CHEMBL3960724 IC50 = 10000.0 nM 5.00
CHEMBL3891718 IC50 = 10000.0 nM 5.00