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Assay Detail

CHEMBL3868099

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Mixed-type inhibition of Trypanosoma brucei TryR assessed as enzyme-substrate-inhibitor complex using TS2 as substrate in presence of NADPH by Lineweaver-Burk plot analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Trypanosoma brucei
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and in vitro antikinetoplastid activity of polyamine-hydroxybenzotriazole conjugates.
Jagu E, Pomel S, Diez-Martinez A, Ramiandrasoa F, Krauth-Siegel RL, Pethe S, Blonski C, Labruère R, Loiseau PM.
Bioorg Med Chem (2017) 25 : 84 -90
PubMed 27793448 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 4.78 4.78

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3981165 1 4.78

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3981165 Ki = 16800.0 nM 4.78