Assay Detail
Binding
CHEMBL3868302
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Inhibition of PI3K-delta in rat whole blood assessed as inhibition of anti-IgM/IL4 induced CD86 expression
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Blood |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel pyrrolidineoxy-substituted heteroaromatics as potent and selective PI3K delta inhibitors with improved physicochemical properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.88 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3944013 | — | — | 1 | 7.46 |
| CHEMBL3947814 | — | — | 1 | 7.18 |
| CHEMBL3977066 | — | — | 1 | 7.14 |
| CHEMBL3966263 | — | — | 1 | 6.55 |
| CHEMBL3896413 | — | — | 1 | 6.53 |
| CHEMBL3905342 | — | — | 1 | 6.42 |
| CHEMBL3939028 | — | — | 1 | - |
| CHEMBL3930000 | — | — | 1 | - |
| CHEMBL3910692 | — | — | 1 | - |
| CHEMBL3921081 | — | — | 1 | - |
| CHEMBL3948901 | — | — | 1 | - |
| CHEMBL3969716 | — | — | 1 | - |
| CHEMBL3914282 | — | — | 1 | - |
| CHEMBL3960012 | — | — | 1 | - |
| CHEMBL3933360 | — | — | 1 | - |
| CHEMBL3977135 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3944013 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3947814 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3977066 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL3966263 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL3896413 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL3905342 | — | IC50 | = | 377.0 | nM | 6.42 |
| CHEMBL3939028 | — | IC50 | - | — | - | |
| CHEMBL3930000 | — | IC50 | - | — | - | |
| CHEMBL3910692 | — | IC50 | - | — | - | |
| CHEMBL3921081 | — | IC50 | - | — | - | |
| CHEMBL3948901 | — | IC50 | - | — | - | |
| CHEMBL3969716 | — | IC50 | - | — | - | |
| CHEMBL3914282 | — | IC50 | - | — | - | |
| CHEMBL3960012 | — | IC50 | - | — | - | |
| CHEMBL3933360 | — | IC50 | - | — | - | |
| CHEMBL3977135 | — | IC50 | - | — | - |