Assay Detail

CHEMBL3868308

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Binding

Inhibition of human recombinant BACE1 by FRET assay

ChEMBL ↗

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Target

Beta-secretase 1 (CHEMBL4822) ↗

Open DB target context

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Beta-secretase 1 (CHEMBL4822) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Beta-secretase 1

CHEMBL4822

Anchored from Assay target.

Protein identity Beta-secretase 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Beta-secretase 1 (CHEMBL4822) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors.

Wu YJ, Guernon J, Rajamani R, Toyn JH, Ahlijanian MK, Albright CF, Muckelbauer J, Chang C, Camac D, Macor JE, Thompson LA.
Bioorg Med Chem Lett (2016) 26 : 5729 -5731
PubMed 27816517 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.70	7.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2396989	LY-2886721	1.0	1	7.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2396989	LY-2886721	IC50	=	20.0	nM	7.70