Assay Detail
Binding
CHEMBL3868309
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Inhibition of BACE1 (unknown origin)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.88 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2396989 | LY-2886721 | 1.0 | 1 | 7.92 |
| CHEMBL3891534 | — | — | 1 | 7.70 |
| CHEMBL3919597 | — | — | 1 | 7.48 |
| CHEMBL3909581 | — | — | 1 | 7.48 |
| CHEMBL3980733 | — | — | 1 | 7.43 |
| CHEMBL3959813 | — | — | 1 | 6.80 |
| CHEMBL3910646 | — | — | 1 | 6.80 |
| CHEMBL3986498 | — | — | 1 | 6.64 |
| CHEMBL3890737 | — | — | 1 | 6.29 |
| CHEMBL3900541 | — | — | 1 | 6.22 |
| CHEMBL3897492 | — | — | 1 | 6.07 |
| CHEMBL3928503 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2396989 | LY-2886721 | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3891534 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3919597 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3909581 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3980733 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3959813 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3910646 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3986498 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3890737 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL3900541 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3897492 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL3928503 | — | IC50 | = | 2000.0 | nM | 5.70 |