Assay Detail
Functional
CHEMBL3868427
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by calcium-4 dye based FLIPR assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
GPR40 agonists for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.80 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3927519 | — | — | 1 | 6.92 |
| CHEMBL3958983 | — | — | 1 | 6.84 |
| CHEMBL3955132 | — | — | 1 | 6.82 |
| CHEMBL3915620 | LY2881835 | 1.0 | 1 | 6.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3927519 | — | EC50 | = | 119.0 | nM | 6.92 |
| CHEMBL3958983 | — | EC50 | = | 146.0 | nM | 6.84 |
| CHEMBL3955132 | — | EC50 | = | 152.0 | nM | 6.82 |
| CHEMBL3915620 | LY2881835 | EC50 | = | 233.0 | nM | 6.63 |