Assay Detail
Binding
CHEMBL3868489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HCV genotype 3a NS3/4A protease assessed as substrate cleavage using Ac-C(Eu)DDMEEAbu(COO)ASK(QSY7)-amide as substrate incubated for 30 mins prior to substrate addition measured after 2.5 hrs by time-resolved fluorescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 3a |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and Synthesis of P2-P4 Macrocycles Containing a Unique Spirocyclic Proline: A New Class of HCV NS3/4A Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 9.21 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3915464 | — | — | 1 | 9.59 |
| CHEMBL3952146 | — | — | 1 | 9.33 |
| CHEMBL3924454 | — | — | 1 | 9.29 |
| CHEMBL3785323 | — | — | 1 | 9.28 |
| CHEMBL3928647 | — | — | 1 | 9.19 |
| CHEMBL3956226 | — | — | 1 | 9.17 |
| CHEMBL3943429 | — | — | 1 | 9.15 |
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | 4.0 | 1 | 9.12 |
| CHEMBL3893915 | — | — | 1 | 9.00 |
| CHEMBL3962860 | — | — | 1 | 8.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3915464 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL3952146 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL3924454 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL3785323 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL3928647 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL3956226 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL3943429 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL3893915 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3962860 | — | IC50 | = | 1.18 | nM | 8.93 |