Assay Detail
Functional
CHEMBL3868495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as reduction viral RNA level after 72 hrs by RT-PCR method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of P2-P4 Macrocycles Containing a Unique Spirocyclic Proline: A New Class of HCV NS3/4A Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 8.92 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | 4.0 | 1 | 9.22 |
| CHEMBL3915464 | — | — | 1 | 9.10 |
| CHEMBL3924454 | — | — | 1 | 9.05 |
| CHEMBL3956226 | — | — | 1 | 9.00 |
| CHEMBL3893915 | — | — | 1 | 9.00 |
| CHEMBL3785323 | — | — | 1 | 8.92 |
| CHEMBL3952146 | — | — | 1 | 8.82 |
| CHEMBL3928647 | — | — | 1 | 8.80 |
| CHEMBL3943429 | — | — | 1 | 8.74 |
| CHEMBL3962860 | — | — | 1 | 8.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3915464 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3924454 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3956226 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3893915 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3785323 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3952146 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3928647 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3943429 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3962860 | — | EC50 | = | 2.8 | nM | 8.55 |