Assay Detail
Binding
CHEMBL3868520
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Agonist activity at LXR-beta in human whole blood assessed as ABCA1 gene induction by measuring ABCA1 mRNA level after 4 hrs by SYBR-Green dye-based Q-PCR analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Highly Potent Liver X Receptor β Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.14 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3910597 | — | — | 1 | 8.30 |
| CHEMBL3945199 | BMS-852927 | 1.0 | 1 | 8.05 |
| CHEMBL3935187 | — | — | 1 | 7.82 |
| CHEMBL3945820 | — | — | 1 | 7.64 |
| CHEMBL3917300 | — | — | 1 | 7.39 |
| CHEMBL3980683 | — | — | 1 | 7.38 |
| CHEMBL3941775 | — | — | 1 | 7.37 |
| CHEMBL3926292 | — | — | 1 | 7.34 |
| CHEMBL3944154 | — | — | 1 | 7.24 |
| CHEMBL3953927 | — | — | 1 | 7.12 |
| CHEMBL3960606 | — | — | 1 | 6.52 |
| CHEMBL3913162 | — | — | 1 | 6.52 |
| CHEMBL3890276 | — | — | 1 | 6.42 |
| CHEMBL3963566 | — | — | 1 | 6.06 |
| CHEMBL3360975 | BMS-779788 | 1.0 | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3910597 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3945199 | BMS-852927 | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3935187 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3945820 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3917300 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3980683 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3941775 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3926292 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3944154 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL3953927 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL3960606 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3913162 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3890276 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL3963566 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3360975 | BMS-779788 | EC50 | = | 1200.0 | nM | 5.92 |