Assay Detail
Binding
CHEMBL3868644
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Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate incubated for 15 mins followed by substrate addition by Ellman's method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.37 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.21 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 6.21 |
| CHEMBL3958859 | — | — | 1 | 5.17 |
| CHEMBL3920392 | — | — | 1 | 5.10 |
| CHEMBL3907011 | — | — | 1 | 4.88 |
| CHEMBL3922437 | — | — | 1 | 4.86 |
| CHEMBL238756 | — | — | 1 | 4.82 |
| CHEMBL3945723 | — | — | 1 | 4.74 |
| CHEMBL459814 | AVAROL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3958859 | — | IC50 | = | 6770.0 | nM | 5.17 |
| CHEMBL3920392 | — | IC50 | = | 7880.0 | nM | 5.10 |
| CHEMBL3907011 | — | IC50 | = | 13090.0 | nM | 4.88 |
| CHEMBL3922437 | — | IC50 | = | 13790.0 | nM | 4.86 |
| CHEMBL238756 | — | IC50 | = | 15110.0 | nM | 4.82 |
| CHEMBL3945723 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL459814 | AVAROL | IC50 | = | 285630.0 | nM | - |