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Assay Detail

CHEMBL3869398

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Binding
Inhibition of Penicillium decumbens alpha-L-rhamnosidase using p-nitrophenyl-glycoside as substrate by spectrophotometric method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Penicillium decumbens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Strategy for designing selective α-l-rhamnosidase inhibitors: Synthesis and biological evaluation of l-DMDP cyclic isothioureas.
Miyawaki S, Hirokami Y, Kinami K, Hoshino M, Minehira D, Miyamoto D, Nash RJ, Fleet GW, Adachi I, Toyooka N, Kato A.
Bioorg Med Chem (2017) 25 : 107 -115
PubMed 27789075 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 5.74 6.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3939102 1 6.64
CHEMBL3967631 1 6.35
CHEMBL3896958 1 6.34
CHEMBL3938029 1 6.16
CHEMBL3948188 1 6.16
CHEMBL3909011 1 6.11
CHEMBL3921691 1 6.10
CHEMBL3907041 1 6.06
CHEMBL3927683 1 6.05
CHEMBL3924503 1 6.00
CHEMBL3985763 1 5.92
CHEMBL3950925 1 5.80
CHEMBL3916051 1 5.80
CHEMBL3954471 1 5.75
CHEMBL3933907 1 5.75
CHEMBL3925011 1 5.66
CHEMBL3920099 1 5.60
CHEMBL3980259 1 5.28
CHEMBL3905898 1 5.17
CHEMBL593715 1 5.00
CHEMBL3910143 1 4.43
CHEMBL3901083 1 4.17
CHEMBL3916914 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3939102 IC50 = 230.0 nM 6.64
CHEMBL3967631 IC50 = 450.0 nM 6.35
CHEMBL3896958 IC50 = 460.0 nM 6.34
CHEMBL3938029 IC50 = 700.0 nM 6.16
CHEMBL3948188 IC50 = 700.0 nM 6.16
CHEMBL3909011 IC50 = 770.0 nM 6.11
CHEMBL3921691 IC50 = 800.0 nM 6.10
CHEMBL3907041 IC50 = 870.0 nM 6.06
CHEMBL3927683 IC50 = 890.0 nM 6.05
CHEMBL3924503 IC50 = 1000.0 nM 6.00
CHEMBL3985763 IC50 = 1200.0 nM 5.92
CHEMBL3950925 IC50 = 1600.0 nM 5.80
CHEMBL3916051 IC50 = 1600.0 nM 5.80
CHEMBL3954471 IC50 = 1800.0 nM 5.75
CHEMBL3933907 IC50 = 1800.0 nM 5.75
CHEMBL3925011 IC50 = 2200.0 nM 5.66
CHEMBL3920099 IC50 = 2500.0 nM 5.60
CHEMBL3980259 IC50 = 5300.0 nM 5.28
CHEMBL3905898 IC50 = 6800.0 nM 5.17
CHEMBL593715 IC50 = 10000.0 nM 5.00
CHEMBL3910143 IC50 = 37000.0 nM 4.43
CHEMBL3901083 IC50 = 67000.0 nM 4.17
CHEMBL3916914 IC50 = 494000.0 nM -