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Assay Detail

CHEMBL3869405

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine liver beta-glucosidase using p-nitrophenyl-glycoside as substrate by spectrophotometric method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Strategy for designing selective α-l-rhamnosidase inhibitors: Synthesis and biological evaluation of l-DMDP cyclic isothioureas.
Miyawaki S, Hirokami Y, Kinami K, Hoshino M, Minehira D, Miyamoto D, Nash RJ, Fleet GW, Adachi I, Toyooka N, Kato A.
Bioorg Med Chem (2017) 25 : 107 -115
PubMed 27789075 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.55 5.02

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3896958 1 5.02
CHEMBL312653 1 5.01
CHEMBL3970812 1 4.80
CHEMBL3935498 1 4.64
CHEMBL3907041 1 4.48
CHEMBL3891002 1 4.44
CHEMBL3939205 1 4.20
CHEMBL3897971 1 4.20
CHEMBL3901083 1 4.20
CHEMBL3944457 1 -
CHEMBL3972215 1 -
CHEMBL3961105 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3896958 IC50 = 9500.0 nM 5.02
CHEMBL312653 IC50 = 9700.0 nM 5.01
CHEMBL3970812 IC50 = 16000.0 nM 4.80
CHEMBL3935498 IC50 = 23000.0 nM 4.64
CHEMBL3907041 IC50 = 33000.0 nM 4.48
CHEMBL3891002 IC50 = 36000.0 nM 4.44
CHEMBL3939205 IC50 = 63000.0 nM 4.20
CHEMBL3897971 IC50 = 63000.0 nM 4.20
CHEMBL3901083 IC50 = 63000.0 nM 4.20
CHEMBL3944457 IC50 = 689000.0 nM -
CHEMBL3972215 IC50 = 939000.0 nM -
CHEMBL3961105 IC50 = 178000.0 nM -