Assay Detail
Binding
CHEMBL3869409
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human lysosomal beta-glucosidase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 45 mins followed by substrate addition measured after 30 mins by fluorescence spectrophotometric method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Strategy for designing selective α-l-rhamnosidase inhibitors: Synthesis and biological evaluation of l-DMDP cyclic isothioureas.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.40 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3935498 | — | — | 1 | 6.80 |
| CHEMBL3907555 | — | — | 1 | 6.13 |
| CHEMBL3897971 | — | — | 1 | 6.00 |
| CHEMBL3901083 | — | — | 1 | 6.00 |
| CHEMBL3939205 | — | — | 1 | 5.62 |
| CHEMBL3944457 | — | — | 1 | 4.92 |
| CHEMBL3916914 | — | — | 1 | 4.80 |
| CHEMBL3970812 | — | — | 1 | 4.19 |
| CHEMBL3891002 | — | — | 1 | 4.14 |
| CHEMBL3943978 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3935498 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3907555 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL3897971 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3901083 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3939205 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3944457 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3916914 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3970812 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL3891002 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL3943978 | — | IC50 | = | 532000.0 | nM | - |