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Assay Detail

CHEMBL3869422

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine liver beta-galactosidase using p-nitrophenyl-glycoside as substrate by spectrophotometric method
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Beta-galactosidase (CHEMBL3482)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Strategy for designing selective α-l-rhamnosidase inhibitors: Synthesis and biological evaluation of l-DMDP cyclic isothioureas.
Miyawaki S, Hirokami Y, Kinami K, Hoshino M, Minehira D, Miyamoto D, Nash RJ, Fleet GW, Adachi I, Toyooka N, Kato A.
Bioorg Med Chem (2017) 25 : 107 -115
PubMed 27789075 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.41 4.96
Inhibition 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3896958 1 4.96
CHEMBL3935498 1 4.62
CHEMBL3891002 1 4.52
CHEMBL3901083 1 4.50
CHEMBL3909011 1 4.44
CHEMBL3970812 1 4.21
CHEMBL3897971 1 4.03
CHEMBL3907555 1 4.00
CHEMBL3907041 1 -
CHEMBL3916518 1 -
CHEMBL3944457 1 -
CHEMBL3972215 1 -
CHEMBL3905255 1 -
CHEMBL3961105 1 -
CHEMBL3910143 1 -
CHEMBL3980259 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3896958 IC50 = 11000.0 nM 4.96
CHEMBL3935498 IC50 = 24000.0 nM 4.62
CHEMBL3891002 IC50 = 30000.0 nM 4.52
CHEMBL3901083 IC50 = 32000.0 nM 4.50
CHEMBL3909011 IC50 = 36000.0 nM 4.44
CHEMBL3970812 IC50 = 61000.0 nM 4.21
CHEMBL3897971 IC50 = 93000.0 nM 4.03
CHEMBL3907555 IC50 = 100000.0 nM 4.00
CHEMBL3907041 Inhibition < 50.0 % -
CHEMBL3916518 IC50 = 1000000.0 nM -
CHEMBL3944457 IC50 = 414000.0 nM -
CHEMBL3972215 IC50 = 473000.0 nM -
CHEMBL3905255 IC50 = 572000.0 nM -
CHEMBL3961105 IC50 = 266000.0 nM -
CHEMBL3910143 IC50 = 719000.0 nM -
CHEMBL3980259 IC50 = 599000.0 nM -