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Assay Detail

CHEMBL3869434

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Penicillium decumbens alpha-L-rhamnosidase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Penicillium decumbens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Strategy for designing selective α-l-rhamnosidase inhibitors: Synthesis and biological evaluation of l-DMDP cyclic isothioureas.
Miyawaki S, Hirokami Y, Kinami K, Hoshino M, Minehira D, Miyamoto D, Nash RJ, Fleet GW, Adachi I, Toyooka N, Kato A.
Bioorg Med Chem (2017) 25 : 107 -115
PubMed 27789075 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 7 5.45 7.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL596461 1 7.50
CHEMBL3913830 1 5.48
CHEMBL608711 1 5.43
CHEMBL593715 1 5.30
CHEMBL1169558 1 4.68
CHEMBL3984167 1 4.28
CHEMBL3955539 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL596461 IC50 = 32.0 nM 7.50
CHEMBL3913830 IC50 = 3300.0 nM 5.48
CHEMBL608711 IC50 = 3700.0 nM 5.43
CHEMBL593715 IC50 = 5000.0 nM 5.30
CHEMBL1169558 IC50 = 21000.0 nM 4.68
CHEMBL3984167 IC50 = 52800.0 nM 4.28
CHEMBL3955539 IC50 = 850000.0 nM -