Assay Detail
ADMET
CHEMBL3870139
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Inhibition of African green monkey SOAT1 expressed in CHO cells assessed as reduction in [14C]cholesteryl ester formation from [1-14C]oleic acid measured after 6 hrs
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Chlorocebus aethiops |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sterol O-acyltransferase 1 (CHEMBL3879850) ↗| Type | SINGLE PROTEIN |
| Organism | Chlorocebus aethiops |
Publication
Discovery of SOAT2 inhibitors from synthetic small molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.92 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3923673 | — | — | 1 | 5.05 |
| CHEMBL3971022 | — | — | 1 | 4.96 |
| CHEMBL3958875 | — | — | 1 | 4.85 |
| CHEMBL3959948 | — | — | 1 | 4.80 |
| CHEMBL3898917 | — | — | 1 | - |
| CHEMBL3932453 | — | — | 1 | - |
| CHEMBL3941429 | — | — | 1 | - |
| CHEMBL3960874 | — | — | 1 | - |
| CHEMBL3983935 | — | — | 1 | - |
| CHEMBL3916935 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3923673 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL3971022 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3958875 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3959948 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3898917 | — | IC50 | > | 28000.0 | nM | - |
| CHEMBL3932453 | — | IC50 | > | 22000.0 | nM | - |
| CHEMBL3941429 | — | IC50 | > | 27000.0 | nM | - |
| CHEMBL3960874 | — | IC50 | > | 23000.0 | nM | - |
| CHEMBL3983935 | — | IC50 | > | 31000.0 | nM | - |
| CHEMBL3916935 | — | IC50 | > | 28000.0 | nM | - |