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Assay Detail

CHEMBL3870401

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Hepatitis C virus genotype 1b (con1) full length C-terminal His-tagged NS3 helicase expressed in Escherichia coli Rosette(DE3) assessed as inhibition of 5'-Cy5/3'-IAbRQ-labeled DNA unwinding activity by molecular beacon assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepatitis C virus (isolate Con1)
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication.
Bassetto M, Leyssen P, Neyts J, Yerukhimovich MM, Frick DN, Brancale A.
Eur J Med Chem (2016) 123 : 31 -47
PubMed 27474921 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 43 5.76 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL275938 AURINTRICARBOXYLIC ACID 1 6.52
CHEMBL3974381 1 5.00
CHEMBL3969033 1 -
CHEMBL3962118 1 -
CHEMBL3965951 1 -
CHEMBL3938439 1 -
CHEMBL3957988 1 -
CHEMBL3904528 1 -
CHEMBL3983525 1 -
CHEMBL3924826 1 -
CHEMBL3964307 1 -
CHEMBL3934190 1 -
CHEMBL3986658 1 -
CHEMBL3919718 1 -
CHEMBL3929888 1 -
CHEMBL3985047 1 -
CHEMBL3976975 1 -
CHEMBL3913532 1 -
CHEMBL3895122 1 -
CHEMBL3983922 1 -
CHEMBL3975416 1 -
CHEMBL3976505 1 -
CHEMBL3985576 1 -
CHEMBL3954549 1 -
CHEMBL3954771 1 -
CHEMBL3967988 1 -
CHEMBL3897847 1 -
CHEMBL3893094 1 -
CHEMBL3974447 1 -
CHEMBL3896780 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL275938 AURINTRICARBOXYLIC ACID IC50 = 300.0 nM 6.52
CHEMBL3974381 IC50 = 10000.0 nM 5.00
CHEMBL3983525 IC50 > 1000000.0 nM -
CHEMBL3905109 IC50 > 1000000.0 nM -
CHEMBL3904528 IC50 > 1000000.0 nM -
CHEMBL3957988 IC50 > 1000000.0 nM -
CHEMBL3938439 IC50 = 250000.0 nM -
CHEMBL3965951 IC50 = 224000.0 nM -
CHEMBL3962118 IC50 = 306000.0 nM -
CHEMBL3969033 IC50 > 1000000.0 nM -
CHEMBL3947214 IC50 > 1000000.0 nM -
CHEMBL3983404 IC50 > 1000000.0 nM -
CHEMBL3984966 IC50 > 1000000.0 nM -
CHEMBL3948302 IC50 > 1000000.0 nM -
CHEMBL3948106 IC50 > 1000000.0 nM -
CHEMBL3937177 IC50 > 1000000.0 nM -
CHEMBL3947706 IC50 > 1000000.0 nM -
CHEMBL3910781 IC50 > 1000000.0 nM -
CHEMBL3932045 IC50 > 1000000.0 nM -
CHEMBL3920486 IC50 > 1000000.0 nM -
CHEMBL3923582 IC50 > 1000000.0 nM -
CHEMBL3892780 IC50 > 1000000.0 nM -
CHEMBL3983922 IC50 > 1000000.0 nM -
CHEMBL3896780 IC50 > 1000000.0 nM -
CHEMBL3974447 IC50 > 1000000.0 nM -
CHEMBL3893094 IC50 > 1000000.0 nM -
CHEMBL3897847 IC50 > 1000000.0 nM -
CHEMBL3967988 IC50 > 1000000.0 nM -
CHEMBL3954771 IC50 > 1000000.0 nM -
CHEMBL3954549 IC50 > 1000000.0 nM -
CHEMBL3985576 IC50 > 1000000.0 nM -
CHEMBL3976505 IC50 > 1000000.0 nM -
CHEMBL3975416 IC50 > 1000000.0 nM -
CHEMBL3924826 IC50 = 229000.0 nM -
CHEMBL3895122 IC50 > 1000000.0 nM -
CHEMBL3913532 IC50 > 1000000.0 nM -
CHEMBL3976975 IC50 > 1000000.0 nM -
CHEMBL3985047 IC50 > 1000000.0 nM -
CHEMBL3929888 IC50 > 1000000.0 nM -
CHEMBL3919718 IC50 > 1000000.0 nM -
CHEMBL3986658 IC50 > 1000000.0 nM -
CHEMBL3934190 IC50 > 1000000.0 nM -
CHEMBL3964307 IC50 > 1000000.0 nM -