Assay Detail
Binding
CHEMBL3870402
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Inhibition of protease domain lacking Hepatitis C virus genotype 1b (con1) C-terminal His-tagged NS3 helicase ATP hydrolysis activity using ATP as substrate preincubated followed by substrate addition measured after 15 mins in presence of poly U RNA by malachite green-based assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus (isolate Con1) |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.85 | 5.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | — | 1 | 5.29 |
| CHEMBL3974381 | — | — | 1 | 4.40 |
| CHEMBL3923582 | — | — | 1 | - |
| CHEMBL3905109 | — | — | 1 | - |
| CHEMBL3924826 | — | — | 1 | - |
| CHEMBL3965951 | — | — | 1 | - |
| CHEMBL3910781 | — | — | 1 | - |
| CHEMBL3986658 | — | — | 1 | - |
| CHEMBL3938439 | — | — | 1 | - |
| CHEMBL3962118 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3974381 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3923582 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL3905109 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL3924826 | — | IC50 | - | — | - | |
| CHEMBL3965951 | — | IC50 | - | — | - | |
| CHEMBL3910781 | — | IC50 | = | 780000.0 | nM | - |
| CHEMBL3986658 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL3938439 | — | IC50 | = | 333000.0 | nM | - |
| CHEMBL3962118 | — | IC50 | - | — | - |