Assay Detail
Binding
CHEMBL3870974
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein-serine O-palmitoleoyltransferase porcupine (CHEMBL1255164) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Development of a triazole class of highly potent Porcn inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 40 | 8.36 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3970245 | — | — | 1 | 10.10 |
| CHEMBL3933984 | — | — | 1 | 9.89 |
| CHEMBL3952126 | — | — | 1 | 9.85 |
| CHEMBL3952665 | — | — | 1 | 9.74 |
| CHEMBL3925918 | — | — | 1 | 9.70 |
| CHEMBL3899701 | — | — | 1 | 9.70 |
| CHEMBL3943764 | — | — | 1 | 9.59 |
| CHEMBL3935037 | — | — | 1 | 9.52 |
| CHEMBL3952501 | — | — | 1 | 9.40 |
| CHEMBL3927718 | — | — | 1 | 9.40 |
| CHEMBL3892208 | — | — | 1 | 9.37 |
| CHEMBL3897216 | — | — | 1 | 9.32 |
| CHEMBL3980962 | — | — | 1 | 9.22 |
| CHEMBL3953544 | — | — | 1 | 9.22 |
| CHEMBL3981277 | — | — | 1 | 9.19 |
| CHEMBL3907204 | — | — | 1 | 9.15 |
| CHEMBL3905849 | — | — | 1 | 8.74 |
| CHEMBL3943114 | — | — | 1 | 8.74 |
| CHEMBL3893457 | — | — | 1 | 8.52 |
| CHEMBL3947115 | — | — | 1 | 8.30 |
| CHEMBL3968025 | — | — | 1 | 8.19 |
| CHEMBL3954145 | — | — | 1 | 8.15 |
| CHEMBL3982830 | — | — | 1 | 8.10 |
| CHEMBL3972297 | — | — | 1 | 8.10 |
| CHEMBL3926685 | — | — | 1 | 8.05 |
| CHEMBL3936691 | — | — | 1 | 8.05 |
| CHEMBL3959152 | — | — | 1 | 7.92 |
| CHEMBL3908085 | — | — | 1 | 7.75 |
| CHEMBL3908747 | — | — | 1 | 7.40 |
| CHEMBL3916470 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3970245 | — | EC50 | = | 0.08 | nM | 10.10 |
| CHEMBL3933984 | — | EC50 | = | 0.13 | nM | 9.89 |
| CHEMBL3952126 | — | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL3952665 | — | EC50 | = | 0.18 | nM | 9.74 |
| CHEMBL3925918 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3899701 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3943764 | — | EC50 | = | 0.26 | nM | 9.59 |
| CHEMBL3935037 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3952501 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3927718 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3892208 | — | EC50 | = | 0.43 | nM | 9.37 |
| CHEMBL3897216 | — | EC50 | = | 0.48 | nM | 9.32 |
| CHEMBL3980962 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3953544 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3981277 | — | EC50 | = | 0.65 | nM | 9.19 |
| CHEMBL3907204 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3905849 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3943114 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3893457 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3947115 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3968025 | — | EC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3954145 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3982830 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3972297 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3926685 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3936691 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3959152 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3908085 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3908747 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3916470 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3893937 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3961192 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3917072 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3986815 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3978552 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3901161 | — | EC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL3889524 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL3963609 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL3917551 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL3945422 | — | EC50 | > | 1000.0 | nM | - |