Assay Detail
ADMET
CHEMBL3871193
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Activity at AMPA receptor in mouse hippocampal brain slices assessed as electrical stimulation-induced excitatory post synaptic potential at -70 mV holding potential by electrophysiology method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.24 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3799213 | — | — | 1 | 5.24 |
| CHEMBL3938522 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3799213 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3938522 | — | EC50 | > | 15000.0 | nM | - |