Assay Detail
Binding
CHEMBL3871570
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type TTR (unknown origin) assessed as inhibition of acid-mediated amyloidogenesis by measuring fibril formation preincubated with enzyme followed by amyloidogenesis stimulation by adjusting pH to 4.4 measured after 72 hrs relative to control
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Systemic optimization and structural evaluation of quinoline derivatives as transthyretin amyloidogenesis inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.72 | 5.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3917629 | — | — | 1 | 5.83 |
| CHEMBL2103837 | TAFAMIDIS | 4.0 | 1 | 5.81 |
| CHEMBL3898378 | — | — | 1 | 5.72 |
| CHEMBL3976323 | — | — | 1 | 5.69 |
| CHEMBL3899454 | — | — | 1 | 5.66 |
| CHEMBL3987064 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3917629 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL2103837 | TAFAMIDIS | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL3898378 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3976323 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL3899454 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL3987064 | — | IC50 | = | 2590.0 | nM | 5.59 |