Assay Detail
Binding
CHEMBL3871604
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged Aurora A (123 to 401 residues) (unknown origin) preincubated for 15 mins followed by tetra(LRRWSLG) substrate addition measured for 90 mins by Kinase-Glo luminescence assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.45 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3986609 | — | — | 1 | 7.58 |
| CHEMBL3946005 | — | — | 1 | 7.29 |
| CHEMBL3983327 | — | — | 1 | 7.22 |
| CHEMBL3923159 | — | — | 1 | 7.18 |
| CHEMBL3975342 | — | — | 1 | 7.13 |
| CHEMBL3939365 | — | — | 1 | 7.08 |
| CHEMBL3953964 | — | — | 1 | 7.07 |
| CHEMBL3922175 | — | — | 1 | 6.68 |
| CHEMBL3912937 | — | — | 1 | 6.58 |
| CHEMBL3901797 | — | — | 1 | 6.58 |
| CHEMBL3974375 | — | — | 1 | 6.51 |
| CHEMBL3935219 | — | — | 1 | 6.50 |
| CHEMBL3894492 | — | — | 1 | 6.32 |
| CHEMBL3954695 | — | — | 1 | 6.32 |
| CHEMBL3961791 | — | — | 1 | 6.10 |
| CHEMBL3929110 | — | — | 1 | 6.10 |
| CHEMBL3909328 | — | — | 1 | 6.02 |
| CHEMBL3901151 | — | — | 1 | 5.78 |
| CHEMBL3901743 | — | — | 1 | 5.54 |
| CHEMBL3972822 | — | — | 1 | 5.02 |
| CHEMBL3970521 | — | — | 1 | 4.87 |
| CHEMBL3946537 | — | — | 1 | - |
| CHEMBL3964280 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3986609 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3946005 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3983327 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3923159 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3975342 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL3939365 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3953964 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL3922175 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL3912937 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3901797 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3974375 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3935219 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL3894492 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3954695 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3961791 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3929110 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3909328 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL3901151 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL3901743 | — | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL3972822 | — | IC50 | = | 9610.0 | nM | 5.02 |
| CHEMBL3970521 | — | IC50 | = | 13560.0 | nM | 4.87 |
| CHEMBL3946537 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3964280 | — | IC50 | > | 1000.0 | nM | - |