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Assay Detail

CHEMBL3871641

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiamoebic activity against Entamoeba histolytica HM-1:IMSS trophozoites after 72 hrs by eosin staining based microdilution method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Entamoeba histolytica
Confidence 1 — Organism
Curated By Autocuration

Target

Entamoeba histolytica (CHEMBL612853)
Type ORGANISM
Organism Entamoeba histolytica

Publication

Synthesis, antiamoebic and molecular docking studies of furan-thiazolidinone hybrids.
Ansari MF, Siddiqui SM, Ahmad K, Avecilla F, Dharavath S, Gourinath S, Azam A.
Eur J Med Chem (2016) 124 : 393 -406
PubMed 27597415 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.78 6.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3926452 1 6.57
CHEMBL3913125 1 6.33
CHEMBL3968421 1 6.17
CHEMBL3976958 1 5.98
CHEMBL3957420 1 5.91
CHEMBL3939464 1 5.87
CHEMBL3930972 1 5.83
CHEMBL137 METRONIDAZOLE 4.0 1 5.79
CHEMBL3981295 1 5.71
CHEMBL3986107 1 5.71
CHEMBL3906260 1 5.69
CHEMBL3958486 1 5.66
CHEMBL3948765 1 5.65
CHEMBL3968932 1 5.63
CHEMBL3957509 1 5.54
CHEMBL3897298 1 5.53
CHEMBL3941140 1 5.45
CHEMBL1558086 1 5.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3926452 IC50 = 270.0 nM 6.57
CHEMBL3913125 IC50 = 470.0 nM 6.33
CHEMBL3968421 IC50 = 670.0 nM 6.17
CHEMBL3976958 IC50 = 1040.0 nM 5.98
CHEMBL3957420 IC50 = 1240.0 nM 5.91
CHEMBL3939464 IC50 = 1350.0 nM 5.87
CHEMBL3930972 IC50 = 1480.0 nM 5.83
CHEMBL137 METRONIDAZOLE IC50 = 1640.0 nM 5.79
CHEMBL3981295 IC50 = 1950.0 nM 5.71
CHEMBL3986107 IC50 = 1950.0 nM 5.71
CHEMBL3906260 IC50 = 2030.0 nM 5.69
CHEMBL3958486 IC50 = 2200.0 nM 5.66
CHEMBL3948765 IC50 = 2250.0 nM 5.65
CHEMBL3968932 IC50 = 2330.0 nM 5.63
CHEMBL3957509 IC50 = 2870.0 nM 5.54
CHEMBL3897298 IC50 = 2970.0 nM 5.53
CHEMBL3941140 IC50 = 3570.0 nM 5.45
CHEMBL1558086 IC50 = 8220.0 nM 5.08