Assay Detail
Binding
CHEMBL3871748
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-FAM-QEDIIRNIARHLAQVGDSMDRSIPPG binding to Mcl-1 (unknown origin) preincubated for 30 mins followed by FAM-labeled peptide addition measured after 20 mins by fluorescence polarization assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino acid side chains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 44 | 6.21 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3962531 | — | — | 1 | 7.11 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 6.75 |
| CHEMBL3908357 | — | — | 1 | 6.66 |
| CHEMBL3972866 | — | — | 1 | 6.58 |
| CHEMBL3918764 | — | — | 1 | 6.52 |
| CHEMBL3899305 | — | — | 1 | 6.50 |
| CHEMBL3965513 | — | — | 1 | 6.48 |
| CHEMBL3901796 | — | — | 1 | 6.47 |
| CHEMBL3910834 | — | — | 1 | 6.39 |
| CHEMBL3919776 | — | — | 1 | 6.37 |
| CHEMBL3892614 | — | — | 1 | 6.34 |
| CHEMBL3952094 | — | — | 1 | 6.32 |
| CHEMBL3901516 | — | — | 1 | 6.30 |
| CHEMBL3956472 | — | — | 1 | 6.30 |
| CHEMBL3953936 | — | — | 1 | 6.30 |
| CHEMBL3735206 | — | — | 1 | 6.28 |
| CHEMBL3945206 | — | — | 1 | 6.27 |
| CHEMBL3945560 | — | — | 1 | 6.25 |
| CHEMBL3735093 | — | — | 1 | 6.25 |
| CHEMBL3890693 | — | — | 1 | 6.24 |
| CHEMBL3736460 | — | — | 1 | 6.24 |
| CHEMBL3985300 | — | — | 1 | 6.23 |
| CHEMBL3736193 | — | — | 1 | 6.20 |
| CHEMBL3899665 | — | — | 1 | 6.17 |
| CHEMBL3928678 | — | — | 1 | 6.15 |
| CHEMBL3893523 | — | — | 1 | 6.14 |
| CHEMBL3892448 | — | — | 1 | 6.13 |
| CHEMBL3980896 | — | — | 1 | 6.11 |
| CHEMBL3917309 | — | — | 1 | 6.11 |
| CHEMBL3927686 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3962531 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL51483 | GOSSYPOL | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL3908357 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL3972866 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL3918764 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL3899305 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL3965513 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL3901796 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL3910834 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL3919776 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL3892614 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL3952094 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL3901516 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL3953936 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL3956472 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL3735206 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL3945206 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL3945560 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL3735093 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL3890693 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL3736460 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL3985300 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL3736193 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL3899665 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL3928678 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL3893523 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL3892448 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL3980896 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL3917309 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL3927686 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL3927341 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL3891727 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL3981494 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL3952775 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL3961955 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL3911506 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL3920440 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL3909769 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL3908716 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3917665 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3926300 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3980936 | — | Ki | - | — | - | |
| CHEMBL3944023 | — | Ki | - | — | - | |
| CHEMBL3916061 | — | Ki | - | — | - |