Assay Detail
Binding
CHEMBL3872473
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Displacement of 125I-Ang2 from AT1 receptor in SPF Sprague-Dawley rat vascular smooth muscle cell membranes after 150 mins by gamma counting method
16
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of novel potent angiotensin II receptor 1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.54 | 9.04 |
| IC50 | 8 | 8.40 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3936495 | — | — | 2 | 9.04 |
| CHEMBL1513 | IRBESARTAN | 4.0 | 2 | 8.98 |
| CHEMBL3893900 | — | — | 2 | 8.66 |
| CHEMBL3974791 | — | — | 2 | 8.47 |
| CHEMBL3945382 | — | — | 2 | 8.33 |
| CHEMBL3962847 | — | — | 2 | 8.33 |
| CHEMBL3966294 | — | — | 2 | 8.29 |
| CHEMBL3954111 | — | — | 2 | 8.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3936495 | — | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL1513 | IRBESARTAN | Ki | = | 1.05 | nM | 8.98 |
| CHEMBL3936495 | — | IC50 | = | 1.26 | nM | 8.90 |
| CHEMBL1513 | IRBESARTAN | IC50 | = | 1.46 | nM | 8.84 |
| CHEMBL3893900 | — | Ki | = | 2.21 | nM | 8.66 |
| CHEMBL3893900 | — | IC50 | = | 3.05 | nM | 8.52 |
| CHEMBL3974791 | — | Ki | = | 3.42 | nM | 8.47 |
| CHEMBL3945382 | — | Ki | = | 4.67 | nM | 8.33 |
| CHEMBL3962847 | — | Ki | = | 4.67 | nM | 8.33 |
| CHEMBL3966294 | — | Ki | = | 5.07 | nM | 8.29 |
| CHEMBL3974791 | — | IC50 | = | 5.33 | nM | 8.27 |
| CHEMBL3954111 | — | Ki | = | 5.61 | nM | 8.25 |
| CHEMBL3945382 | — | IC50 | = | 6.15 | nM | 8.21 |
| CHEMBL3962847 | — | IC50 | = | 6.15 | nM | 8.21 |
| CHEMBL3966294 | — | IC50 | = | 7.04 | nM | 8.15 |
| CHEMBL3954111 | — | IC50 | = | 7.75 | nM | 8.11 |