Assay Detail
Binding
CHEMBL3872973
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Inhibition of Leishmania major recombinant N-terminal hexa-His tagged PTR1 catalytic activity expressed in Escherichia coli BL21(DE3) using biopterin as substrate measured for 60 sec in presence of NADPH by UV-visible spectrophotometric method relative to control
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Leishmania major |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-guided discovery of thiazolidine-2,4-dione derivatives as a novel class of Leishmania major pteridine reductase 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.24 | 4.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3905744 | — | — | 1 | 4.35 |
| CHEMBL3933757 | — | — | 1 | 4.12 |
| CHEMBL3942723 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3905744 | — | IC50 | = | 44670.0 | nM | 4.35 |
| CHEMBL3933757 | — | IC50 | = | 75860.0 | nM | 4.12 |
| CHEMBL3942723 | — | IC50 | = | 588840.0 | nM | - |