Assay Detail
Binding
CHEMBL3873357
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-flunitrazepam from rat brain GABA-A receptor benzodiazepine site after 20 mins by liquid scintillation counting
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of fluorinated imidazo[1,2-a]pyridine derivatives with potential antipsychotic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.86 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3962969 | — | — | 1 | 7.60 |
| CHEMBL911 | ZOLPIDEM | 4.0 | 1 | 7.36 |
| CHEMBL3954951 | — | — | 1 | 7.25 |
| CHEMBL3975584 | — | — | 1 | 7.24 |
| CHEMBL3971200 | — | — | 1 | 7.22 |
| CHEMBL3970126 | — | — | 1 | 7.17 |
| CHEMBL3979360 | — | — | 1 | 6.89 |
| CHEMBL3959035 | — | — | 1 | 6.85 |
| CHEMBL3890007 | — | — | 1 | 6.75 |
| CHEMBL3983568 | — | — | 1 | 6.31 |
| CHEMBL3894769 | — | — | 1 | 6.29 |
| CHEMBL3937382 | — | — | 1 | 6.14 |
| CHEMBL3966116 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3962969 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL911 | ZOLPIDEM | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL3954951 | — | Ki | = | 55.6 | nM | 7.25 |
| CHEMBL3975584 | — | Ki | = | 57.5 | nM | 7.24 |
| CHEMBL3971200 | — | Ki | = | 59.6 | nM | 7.22 |
| CHEMBL3970126 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL3979360 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL3959035 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL3890007 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL3983568 | — | Ki | = | 487.0 | nM | 6.31 |
| CHEMBL3894769 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL3937382 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL3966116 | — | Ki | = | 830.0 | nM | 6.08 |