Assay Detail
Binding
CHEMBL3873939
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Inhibition of wild-type HCV genotype 1b Con1 C-terminal truncated NS5B RNA dependent RNA polymerase expressed in Escherichia coli BL21(DE3) Star assessed as inhibition of [alpha-32P]UTP incorporation using polyrA/T12 as template/primer measured after 60 mins by TopCount NXT method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus (isolate Con1) |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.19 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3940281 | — | — | 1 | 6.06 |
| CHEMBL3957330 | — | — | 1 | 5.92 |
| CHEMBL3921421 | — | — | 1 | 5.77 |
| CHEMBL3929755 | — | — | 1 | 5.68 |
| CHEMBL3902898 | — | — | 1 | 5.36 |
| CHEMBL3920853 | — | — | 1 | 5.34 |
| CHEMBL3983325 | — | — | 1 | 5.21 |
| CHEMBL3930888 | — | — | 1 | 5.18 |
| CHEMBL3902813 | — | — | 1 | 5.08 |
| CHEMBL3982375 | — | — | 1 | 5.08 |
| CHEMBL3947576 | — | — | 1 | 5.06 |
| CHEMBL3903438 | — | — | 1 | 5.00 |
| CHEMBL3893403 | — | — | 1 | 4.96 |
| CHEMBL3892823 | — | — | 1 | 4.82 |
| CHEMBL3974374 | — | — | 1 | 4.62 |
| CHEMBL3902396 | — | — | 1 | 4.60 |
| CHEMBL3948659 | — | — | 1 | 4.50 |
| CHEMBL3930375 | — | — | 1 | - |
| CHEMBL3912461 | — | — | 1 | - |
| CHEMBL3976844 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3940281 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL3957330 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3921421 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3929755 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3902898 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3920853 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3983325 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3930888 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL3902813 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL3982375 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3947576 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL3903438 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3893403 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3892823 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3974374 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3902396 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3948659 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL3930375 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3912461 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3976844 | — | IC50 | > | 50000.0 | nM | - |