Assay Detail
Binding
CHEMBL3874760
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Inhibition of human recombinant carbonic anhydrase-9 preincubated for 6 hrs by stopped-flow CO2 hydration assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.88 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3986431 | — | — | 1 | 7.96 |
| CHEMBL3956977 | — | — | 1 | 7.82 |
| CHEMBL3977549 | — | — | 1 | 7.74 |
| CHEMBL3896854 | — | — | 1 | 7.70 |
| CHEMBL3928695 | — | — | 1 | 7.67 |
| CHEMBL3960492 | — | — | 1 | 7.61 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL3976024 | — | — | 1 | 7.06 |
| CHEMBL3984047 | — | — | 1 | 6.94 |
| CHEMBL1993421 | — | — | 1 | 6.46 |
| CHEMBL3914224 | — | — | 1 | 5.26 |
| CHEMBL421646 | BENZOYLENUREA | — | 1 | 4.86 |
| CHEMBL266540 | QUINAZOLINONE | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3986431 | — | Ki | = | 10.9 | nM | 7.96 |
| CHEMBL3956977 | — | Ki | = | 15.1 | nM | 7.82 |
| CHEMBL3977549 | — | Ki | = | 18.4 | nM | 7.74 |
| CHEMBL3896854 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL3928695 | — | Ki | = | 21.6 | nM | 7.67 |
| CHEMBL3960492 | — | Ki | = | 24.5 | nM | 7.61 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL3976024 | — | Ki | = | 87.4 | nM | 7.06 |
| CHEMBL3984047 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL1993421 | — | Ki | = | 349.0 | nM | 6.46 |
| CHEMBL3914224 | — | Ki | = | 5470.0 | nM | 5.26 |
| CHEMBL421646 | BENZOYLENUREA | Ki | = | 13700.0 | nM | 4.86 |
| CHEMBL266540 | QUINAZOLINONE | Ki | = | 15700.0 | nM | 4.80 |