Assay Detail
Binding
CHEMBL3874976
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Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitment
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.52 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3896657 | — | — | 1 | 7.80 |
| CHEMBL3909872 | — | — | 1 | 5.96 |
| CHEMBL3933619 | — | — | 1 | 5.80 |
| CHEMBL3964985 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3896657 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3909872 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3933619 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3964985 | — | EC50 | > | 10000.0 | nM | - |