Assay Detail
Binding
CHEMBL3874977
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Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.91 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3896657 | — | — | 1 | 7.68 |
| CHEMBL3909872 | — | — | 1 | 7.46 |
| CHEMBL3933619 | — | — | 1 | 6.50 |
| CHEMBL3906716 | — | — | 1 | 6.00 |
| CHEMBL3964985 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3896657 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3909872 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3933619 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3906716 | — | EC50 | = | 990.0 | nM | 6.00 |
| CHEMBL3964985 | — | EC50 | > | 10000.0 | nM | - |