Assay Detail
Binding
CHEMBL3875325
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Staphylococcus aureus WCUH29 DNA gyrase expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells assessed as inhibition of DNA supercoiling activity using relaxed pBR322 as substrate incubated for 30 mins in presence of ATP by ethidium bromide staining based agarose gel electrophoresis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Mycobacterium Tuberculosis (MTB) GyrB inhibitors: An attractive approach for developing novel drugs against TB.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.66 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242550 | DIOSPYRIN | — | 1 | 5.10 |
| CHEMBL430853 | RAMENTACEONE | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242550 | DIOSPYRIN | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL430853 | RAMENTACEONE | IC50 | = | 60000.0 | nM | 4.22 |